Copper-catalyzed regioselective hydroboration of terminal alkynes in aqueous medium
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چکیده
منابع مشابه
Copper-catalyzed regioselective reaction of internal alkynes and diaryliodonium salts.
The copper-catalyzed highly regioselective reaction of internal alkynes with diaryliodonium salts was achieved for the first time. α-Arylketones were obtained in moderate to good yields from arylpropargylic alcohols or aryl alkyl alkynes under mild conditions. It was found that the two kinds of substrates underwent two different arylation-oxygenation pathways under different reaction conditions...
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A simple and convenient copper-catalyzed hydroamination of arylacetylenes with secondary amines has been performed giving a simple access to aliphatic amines after reduction of the hydroaminated products (E-enamines). Here we described a mild catalytic system utilizing CuCN precatalyst without any additive ligands in a solvent-free system.
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Annulation of internal alkynes with functionalized aryl halides is a versatile and useful method for the synthesis of a wide variety of carboand heterocycles (Fig. 1). To date, many homogeneous transition metal-based catalytic systems have been developed for this transformation. Although homogeneous catalysis have many advantages, difficulties in separation and recovery of the catalyst and prod...
متن کاملCopper-catalyzed dehydrogenative borylation of terminal alkynes with pinacolborane.
LCuOTf complexes [L = cyclic (alkyl)(amino)carbenes (CAACs) or N-heterocyclic carbenes (NHCs)] selectively promote the dehydrogenative borylation of C(sp)-H bonds at room temperature. It is shown that σ,π-bis(copper) acetylide and copper hydride complexes are the key catalytic species.
متن کاملCopper-catalyzed distannylation of alkynes.
A copper(I)-phosphine complex has been found to facilely promote the distannylation of alkynes with the aid of a base, where a catalytically generated Cu-Sn species serves as a key intermediate. The broad versatility of the copper catalysis has been demonstrated by the facile distannylation of unfunctionalized aliphatic alkynes, being hardly achievable with the conventional palladium catalysts.
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ژورنال
عنوان ژورنال: Tetrahedron Letters
سال: 2016
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2016.01.049